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Little Argyll Street is a short street connecting Argyll Street to Regent Street, at the north-western edge of Soho near Oxford Circus. It belongs to the development of the Argyll estate, named after John Campbell, second Duke of Argyll, who acquired a large property on the south side of Oxford Street in the early eighteenth century. A newspaper notice of September 1736 described the scheme as two rows of fine houses with a fine street cut through the Duke's house, that street being Little Argyll Street.
The setting places it among some of the West End's better-known landmarks. The London Palladium stands on Argyll Street, and the Argyll Arms, a Grade II* listed Victorian public house, sits beside Oxford Circus station. An entrance to the Bakerloo line platforms at Oxford Circus opened on the corner of Argyll Street and Oxford Street in 1906.
Today Little Argyll Street is a quiet link in a busy quarter, given over largely to offices and shops, a short walk from the retail of Regent Street and the shopping lanes around Carnaby Street to the east.